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There is a lack of evidence to recommend supplemental vitamin D intake in older age groups. However, a systematic review ( 2) commissioned by the Agency for Healthcare Research and Quality found inconsistent associations between infant 25(OH)D concentrations and either rickets or measures of bone mineral mass.

In newborns, 400 IU/day of vitamin D 3 has been shown to maintain the serum concentration of 25-hydroxyvitamin D (25D) above the range classically associated with rickets ( 5). Therefore, it is instructive to review the evidence base that guides nutritional recommendations regarding vitamin D supplementation from infancy to adolescence.Ī Cochrane Collaboration review updated in 2007 ( 4) found evidence that 400 IU/day of vitamin D for 12 months prevented nutritional rickets in children aged three to 36 months in rural Turkey, and that 300 IU/day of vitamin D for at least the first 12 months of life (a calcium supplement was also added from five months of age) reduced the risk of rickets by 24% in China. The apparent re-emergence of nutritional rickets ( 1) and reported bone ( 2) and extraskeletal ( 3) benefits of vitamin D supplementation in adults are leading Canadian physicians to face frequent questions about vitamin D. PART A: EVIDENCE-BASED ANSWER AND SUMMARY

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